Behind the Pathophysiology of Fibromyalgia


Diseases and other physical conditions possess their own individual changes and physiological processes. For this reason, doctors and medical scientists read the pathophysiology of those conditions.

Pathophysiology is a term describing the physiological processes linked to injury or diseases. Quite simply, it describes any functional changes related to injuries or diseases.

  • Pathology, a medical discipline describing conditions that are observed as a disease state
  • Physiology, the biological discipline describing mechanisms or processes that operate within an organism.

As a singular term, pathophysiology is used to explain the physiological processes associated with the growth and development of an ailment or disease. Doctors and medical scientists use pathophysiology to study how injuries and diseases affect people, especially when they study a single disease or injury.

Fibromyalgia is a very common subject of pathophysiology studies, because the condition itself is shrouded in mystery regarding its origin or, rather, cause.

The real picture which makes fibromyalgia complex is the fact that individuals with this issue often show hyper-sensitivity to numerous painful and non-painful ‘causes of stimulation,’ while also exhibiting an altered physiological response to painful stimulation via the spinal cord.

While there are various studies about fibromyalgia, many medical resources don’t yet understand how the mechanisms behind the condition actually modify the body. The things they’re doing seem to comprehend is that the pathophysiology of fibromyalgia can help them find out methods to organize factors that can help recognize how the problem manifests in people. In this article, we’re going to review the known pathophysiology of fibromyalgia.

The pathophysiology of fibromyalgia: about fibromyalgia

Fibromyalgia is a condition commonly characterized by its widespread bodily pain, fatigue, sleep issues, cognitive dysfunction and depression symptoms.

Fibromyalgia affects millions all over the world. It’s said to affect as much as ‘One in 20 people worldwide.’ In the usa alone, around 10 percent from the general population are affected by fibromyalgia. The problem affects both women and men, but women are ‘7 times more prone to develop’ over men.

This condition commonly affects people between the ages of 30 and 60. It could also develop in children and elderly people. ?The precise cause behind fibromyalgia isn’t known. Interestingly enough, immune system disturbances, hormonal changes and also the impairment of the body’s pain pathways have been discovered to play a job in affecting patients using the condition.

Even though fibromyalgia seems like an actual disorder, the dysfunction from the brain’s chemical (neurotransmitters) function also appear to play a sizable role in the development of the problem. This more or less suggests a multifaceted ’cause’ behind the condition, however medical scientists and doctors continue to be learning why that may be the case in the end.

Fibromyalgia is recognized as part of a family of disorders referred to as affective spectrum disorders or ASD. This group of disorders includes major depressive disorder, post-traumatic stress disorder, generalized anxiety disorder, ibs attention-deficit or hyperactivity disorder and migraines.

The pathophysiology of fibromyalgia actually reveals that fibromyalgia shares some characteristics, pathologies and manifestations related to other affective spectrum disorders. The pathophysiology of fibromyalgia includes several aspects it shares with other conditions, for example:

  • Environmental triggers
  • Psychosocial factors
  • Genetic factors
  • Neuro-endocrine issues
  • Problems using the autonomic nervous system

In the next section, we’re likely to take a look at several aspects associated with the pathophysiology of fibromyalgia and other conditions.

The pathophysiology of fibromyalgia: the aspects

Behind every condition or disease, there are several aspects that influence its development. That’s something that the pathophysiology of fibromyalgia has revealed to researchers through the years.

Environmental causes

Fibromyalgia actually has lots of environmental causes that might influence the development of the condition. Several of those causes can include physical trauma, injury, psychosocial stress, abuse and emotional trauma.

The pathophysiology of fibromyalgia has additionally revealed that fibromyalgia shares common symptoms along with other conditions that often develop in individuals with fibromyalgia. Major despression symptoms, panic attacks and depression are common disorders contained in people with fibromyalgia.

Genetic factors

Several genetics lead to the pathophysiology of fibromyalgia, in addition to conditions linked to the disorder. One study revealed that the regularity of fibromyalgia in patients with first relatives who had fibromyalgia genetic makeup involved 6.4 %. The typical quantity of ‘tender points’ the type of relatives was 17 from the 18 points tested at that time. The serotonin transporter gene (5-HTT) is said to experience a role in enhanced pain sensitivity.

Problems with the autonomic nervous system

People with fibromyalgia often experience issues with their autonomic central nervous system. It causes increased pain and significantly impairs the body’s ability to manage stress. The condition may also cause decreases in blood pressure level, in addition to decreased pain inhibition, since it stops the body from producing normal levels of growth hormone and growth factor.

Neuro-endocrine issues and sleep problems

Psychological stress and fibromyalgia share lots of symptoms. Fibromyalgia is also associated with the body’s wherewithal to suppress cortisol, the body’s stress hormone.

People with fibromyalgia also experience issues with sleep. Even though studies haven’t found whether sleep problems cause the condition, there’s a definite association forwards and backwards.

People using the condition often report installments of insomnia, early morning awakening and poor sleeping habits.

Problems with pain sensitivity

People with fibromyalgia often benefit by an increased sensitivity to any type of pain sensation. They’re characteristically ‘more sensitive’ to cold and hot sensations and could experience bodily pressure from a lack of blood flow.

On a fascinating note, the abnormal levels of norepinephrine and serotonin (neurotransmitters from the brain) have been demonstrated to have some influence behind increased pain sensitivity. The disruption of signals inside the brain may contribute to resulting in the characteristic increased pain sensitivity in patients with this particular condition.

Closing thoughts

The pathophysiology of fibromyalgia helps both doctors and medical researchers learn more about the chronic condition. Since various conditions share factors that relate towards the growth and development of fibromyalgia, it’s important to comprehend the relationship between fibromyalgia and other problems that often co-exist by using it.

Understanding the pathophysiology of fibromyalgia may ultimately help doctors and researchers develop , too.